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研究生: 高維聰
研究生(外文): Wei-Tsung, Kao
論文名稱: 雄激素接收體基因在擁有同性性取向之年輕男性的表現
論文名稱(外文): Androgen receptor gene in Young Males with Same-Sex Orientation
指導教授: 朱元祥,龍佛衛
指導教授(外文): Yuan-Hsiang, Chu For-Wey, Lung
學位類別: 碩士
校院名稱: 樹德科技大學
系所名稱: 人類性學研究所
論文出版年: 2009
畢業學年度: 97
語文別: 中文
論文頁數: 78
中文關鍵詞: 雄激素接收體基因同性戀被甲基化
外文關鍵詞: Androgen receptor geneHomosexualityMethylation
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目的:探討雄激素接收體基因 CAG repeats長度及雄激素接收體基因被甲基化的百分比會不會對性取向造成影響。希望藉此讓我們對於人類性取向的行為是如何形成的,有進一步的瞭解。方法:本研究採用病例對照研究設計(case-control study),病例組共收集了52位「同性戀組」個案,而對照組共收集了708位「環境適應障礙組」個案及62位為「正常組」個案,分別取得人口學相關資料及進行研究相關問卷之施測,並抽取其靜脈血液來做DNA萃取及基因分析,包括雄激素接收體基因 CAG repeats長度及雄激素接收體基因被甲基化的百分比。結果: 「正常組」的受教育年限較「同性戀組」與「環境適應障礙組」為長,得F=4.073(P=0.018<0.05)。「同性戀組」與「正常組」的雄激素接收體基因 CAG repeats 長度較「環境適應障礙組」短,但以單因子變異數分析(ANOVA)分析,發現並未達到統計學上的顯著差異。「同性戀組」個案中,「低比例組」所佔比例較「環境適應障礙組」與「正常組」為高,而「環境適應障礙組」個案中,「低比例組」所佔比例較「正常組」為高,但以卡方檢定分析,發現並未達到統計學上的顯著差異。以t-test來分析「低比例組」與「高比例組」個案在雄激素接收體基因 CAG repeats 長度分布上的差異,發現未達到統計學上的顯著差異。討論: Multiple logistic regression顯示「同性戀組」個案有較高的外向性,有較高父親保護及較低母親關懷的個案較易形成同性戀。於研究結果中顯示,三組研究對象在雄激素接收體基因 CAG repeats長度與雄激素接收體基因被甲基化百分比「低比例組」及「高比例組」分布皆沒有達到統計學上的差異,可能是因為個案數目仍然太少及雄激素接收體基因被甲基化的實驗結果有反應的個案數目太少。雄激素對於性取向的影響,是在出生前的時候便產生影響,而我們目前要去評估「同性戀」在出生前,其所接受到的雄激素曝露程度有一定的困難,出生世代研究(Birth Cohort Study)才有辦法加以分析探討。
Object:Explore the influence of androgen receptor gene CAG repeats and the percentage of androgen receptor gene methylation on sexual orientation. On the other hand, we hope to understand the formulation of human sexual orientation by the study. Method:We used case-control study in our research which included 52 Homosexuality subjects, 708 adjustment disorder subjects and 62 normal subjects. Demographic data and research related questionnaires were collected. We also drew veinous blood for DNA extraction and gene analysis that included androgen receptor gene CAG repeats and the percentage of androgen receptor gene methylation.
Result:The education years of Normal subjects are longer than Homosexuality subjects and adjustment disorder subjects,F=4.073(P=0.018<0.05)。The androgen receptor gene CAG repeats of Homosexuality subjects and normal subjects are shorter than adjustment disorder subjects,but after ANOVA analysis, there is no statistic significant difference. For androgen receptor gene methylation, the percentage of low ratio group in Homosexuality subjects is higher than adjustment disorder subjects and normal subjects. The percentage of low ratio group in adjustment disorder subjects is higher than normal subjects. After χ2 test, there is no statistic significant difference. By t-test analysis, there is no statistic significant difference in the distribution of androgen receptor gene CAG repeats between low ratio group and high ratio group.
Discussion:Multiple logistic regression showed that Homosexuality subjects has higher extravision. Higher father protect and lower mother care more easily became to Homosexuality subjects. In our research, there is no statistic significant difference in the distribution of androgen receptor gene CAG repeats and androgen receptor gene methylation between three groups. The possible reason is case number is too less and laboratory responded number of androgen receptor gene methylation is also too less. The influence of androgen on sexual orientation is prenatal. Now we had difficult to evaluate the exposed level of androgen level. Only birth cohort study can explore it.
目      錄
中文摘要                                                I
英文摘要                                              II
誌謝                                                  IV
目錄                                                    V
表目錄                                              VIII
圖目錄                                                IX

第一章  緒論                                            1
第一節  研究動機                              1
第二節  研究目的                              5
第三節  研究假設                              6
第四節  研究限制                              7
第五節  名詞釋義                              8
第二章  文獻探討                                      11
第一節  「同性戀」相關的各個層面的探討        11
第二節  性取向與雄激素的關係                  18
第三節  性取向與雄激素的關係                  21
第三章  研究方法                                      23
第一節  研究收案                              23
第二節  研究設計與架構                        25
第三節  實驗分析                              26
第四節  研究問卷                              29
第五節  研究資料分析                          31
第四章  研究結果                                      32
        第一節  三組研究對象在人口學變項上、心理健康程度、人格特質及雙親教養態度的情形          32
        第二節  擁有相同性取向之年輕男性的個案與其他兩組的雄激素接收體基因 CAG repeats長度與雄激素接收體基因被甲基化的百分比的情形        44
        第三節  探討雄激素接收體基因 CAG repeats長度與雄激素接收體基因被甲基化的百分比的關聯性  48
第五章  討論                                          50
第一節  心理健康程度、人格特質及雙親教養態度差異的探討                                  50
第二節  探討雄激素接收體基因 CAG repeats長度與雄激素接收體基因被甲基化的百分比在三組研究對象上所表現的差異及其關聯性              55
第三節  探討心理健康程度、人格特質及雙親教養態度與雄激素接收體基因 CAG repeats長度與雄激素接收體基因被甲基化百分比的關聯性        58
第六章  結論與未來研究可以進行的方向
第一節  結論                                  60
第二節  未來研究可以進行的方向                62
參考文獻                                              66
附件一                                                72
問卷一                                                74
問卷二                                                76
問卷三                                                77
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