The purpose of this study is to investigate the current situation and relevance in leisure participation life stress depression on junior high school students in Tainan City, and comparing the relationship between leisure participation life stres and depression in different background. The study is based on questionnaire surver, and junior high school students in Tainan City as the research objects, research tool as “The effect on leisure join, stress of life and the mood of melancholy of junior high school students in Tainan City”. In this study, we are using frequency distribution, percentage of independent sample t-test, single factor analysis of variance, and person correlation analysis to analyze the data. The results showed: The leisure participation of junior high school students in Tainan tends to be static, easy and enteraining. Men’s life stress from family are more than women, however, junior high school students most commonly feel that depression is in the physiological aspect. There are significant differences in leisure participation, life stress and depressive mood along with different background variables (like gender, grade, parents or parent, parental education, pocket money, the amount of weekly exercise days, and time of each exercise). When it comes to the relevant aspects, the physical type, peers, individuals, congnition, and emotion show negative correlation. Entertainment, behaviors, and emotion show positive correlation. The literary arts type, family, individuals, and the physiological aspect show positive correlation, but positively relate to life stress and depression. The results can be used as a reference for leisure activeities for future planning of the junior high school students.