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Preparation and Validity Evaluation of Methoxycinnamic Acid Solid nano-lipid and Liposome
methoxycinnamic acid;liposome;solid nano-lipid
|Issue Date: ||2012-12-11 15:16:24 (UTC+8)|
This study prepared different nano-carriers using different limpid formulations with methoxycinnamic acid as the main sunscreen material, compared the lipids and weight ratios. The samples were placed in the environment of 4℃ to observe the changes of particle size to evaluate the effectiveness and stability.
The experimental results showed that the particle size of solid nano-lipid in the environment of 4℃ in the 28th day increased by 70.8 nm, as compared with the first day of storage. Since the difference was insignificant, it was more stable than other methods.
The average HPF value of the solid nano-lipid prepared using the high pressure homogenization emulsification method was 6.1, which is the best among all the preparation methods. In the permeability assessment, its absorption wave number of standard material had the fewest differences. The experimental results showed that the stability of the solid nano-lipid prepared by high pressure homogenization approach after 28 days of storage was the highest. The anti-UV function of OMC coupled with the coating of SLN could enhance UV resistance to form a protective membrane on the gross phosphorus layer, making the hair black and beautiful.
In the moisture test, the water loss rate of the hair specimens using solid nano-lipid was 15.89%, and the water retention rate was the best. In the anti-UV analysis experimental tests, the one with the greatest differences was solid nano-lipid: △L value is -3.01, color difference △E value is about 5.37, proving that the hair color cannot easily fade in exposure to sunlight after using the solid nano-lipid. Regarding the skin allergy testing, after 48 hours of the skin patch test, the one with the highest score was the lipid of liposome with addition of triglyceride lipid, and SLN had the lowest score with almost no redness and allergy, proving that the preparation method of this type can produce safer carriers.
|Appears in Collections:||[應用設計研究所] 博碩士論文|
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